Reading Books is Great, But Not if You Are Driving! Visually Grounded Reasoning about Defeasible Commonsense Norms

Commonsense norms are defeasible by context: reading books is usually great, but not when driving a car. While contexts can be explicitly described in language, in embodied scenarios, contexts are often provided visually. This type of visually grounded reasoning about defeasible commonsense norms is generally easy for humans, but (as we show) poses a challenge for machines, as it necessitates both visual understanding and reasoning about commonsense norms. We construct a new multimodal benchmark for studying visual-grounded commonsense norms: NORMLENS. NORMLENS consists of 10K human judgments accompanied by free-form explanations covering 2K multimodal situations, and serves as a probe to address two questions: (1) to what extent can models align with average human judgment? and (2) how well can models explain their predicted judgments? We find that state-of-the-art model judgments and explanations are not well-aligned with human annotation. Additionally, we present a new approach to better align models with humans by distilling social commonsense knowledge from large language models. The data and code are released at https://seungjuhan.me/normlens.Comment: Published as a conference paper at EMNLP 2023 (long

Electrically Polarized Graphene-Blended Spacers for Organic Fouling Reduction in Forward Osmosis

In membrane processes, a spacer is known to play a key role in the mitigation of membrane fouling. In this study, the effect of electric polarization on a graphene-blended polymer spacer (e.g., poly(lactic acid), PLA) for organic fouling on membrane surfaces was investigated. A pristine PLA spacer (P-S), a graphene-blended spacer (G-S), and an electrically polarized graphene-blended spacer (EG-S) were successfully fabricated by 3D printing. Organic fouling tests were conducted by the 5-h filtration of CaCl2 and a sodium alginate solution through commercially available membranes, which were placed together with the fabricated spacers. Membranes utilizing P-S, G-S, and EG-S were characterized in terms of the fouling amount on the membrane surface and fouling roughness. Electrostatic forces of EG-S provided 70% less and 90% smoother fouling on the membrane surface, leading to an only 14% less water flux reduction after 5 h of fouling. The importance of nanomaterial blending and polarization was successfully demonstrated herein

Combined Effects of Nutrients × Water × Light on Metabolite Composition in Tomato Fruits (Solanum Lycopersicum L.)

Tomato cultivation in the greenhouse can be facilitated by supplemental light. We compared the combined effects of nutrients, water, and supplemental light (red) on tomato fruit quality. To do this, three different nutrient conditions were tested, i.e., (1) low N, (2) standard N, and (3) high N. Water was supplied either at −30 kPa (sufficient) or −80 kPa (limited) of soil water potential. Supplemental red LED light was turned either on or off. The metabolites from tomato fruits were profiled using non-targeted mass spectrometry (MS)-based metabolomic approaches. The lycopene content was highest in the condition of high N and limited water in the absence of supplemental light. In the absence of red lighting, the lycopene contents were greatly affected by nutrient and water conditions. Under the red lighting, the nutrient and water conditions did not play an important role in enhancing lycopene content. Lower N resulted in low amino acids. Low N was also likely to enhance some soluble carbohydrates. Interestingly, the combination of low N and red light led to a significant increase in sucrose, maltose, and flavonoids. In high N soil, red light increased a majority of amino acids, including aspartic acid and GABA, and sugars. However, it decreased most of the secondary metabolites such as phenylpropanoids, polyamines, and alkaloids. The water supply effect was minor. We demonstrated that different nutrient conditions of soil resulted in a difference in metabolic composition in tomato fruits and the effect of red light was variable depending on nutrient conditions

Electrospun RuO2-Co3O4 hybrid nanotubes for enhanced electrocatalytic activity

We report a facile synthesis of electrospun RuO2-Co3O4hybrid nanotubes as well as their enhanced electrochemical responses. Among all RuO2-Co3O4hybrid nanotubes, the polycrystalline RuO2-Co3O4hybrid nanotubes with optimum relative atomic ratios of Ru/Co=2.3:1.0 show the highly efficient catalytic activity for oxygen reduction reaction (ORR). Additionally, the nanotubes represent the favorable electrochemical sensing behavior for ascorbic acid, resulting in the high sensitivity of 204 μAmM-1cm-2, the low detection limit of 6.6 μM, and the broad dynamic range without the interference from other biological relevant species. © 2014 Published by Elsevier B.V.

Effects of Salt Treatment Time on the Metabolites, Microbial Composition, and Quality Characteristics of the Soy Sauce Moromi Extract

Salt is one of the most important factors for fermented foods, but the effect of salt treatment time on the quality of fermented foods has rarely been studied. In this study, the effect of different salt treatment times (0, 48, and 96 h) after the start of fermentation on the quality of the soy sauce moromi extract (SSME) was investigated. As the salt treatment time was delayed, the population of Aspergillus oryzae, Lactobacillaceae, and Enterococcaecea in SSME increased, whereas the population of Staphylococcaceae and Bacillaceae decreased, leading to changes in the enzymatic activity and metabolite profiles. In particular, the contents of amino acids, peptides, volatile compounds, acidic compounds, sugars, and secondary metabolites were significantly affected by the salt treatment time, resulting in changes in the sensory quality and appearance of SSME. The correlation data showed that metabolites, bacterial population, and sensory parameters had strong positive or negative correlations with each other. Moreover, based on metabolomics analysis, the salt treatment-time-related SSME metabolomic pathway was proposed. Although further studies are needed to elucidate the salt treatment mechanism in fermented foods, our data can be useful to better understand the effect of salt treatment time on the quality of fermented foods

Promising Therapeutic Efficacy of GC1118, an Anti-EGFR Antibody, against KRAS Mutation-Driven Colorectal Cancer Patient-Derived Xenografts

Epidermal growth factor receptor (EGFR)-targeted monoclonal antibodies, including cetuximab and panitumumab, are used to treat metastatic colorectal cancer (mCRC). However, this treatment is only effective for a small subset of mCRC patients positive for the wild-type KRAS GTPase. GC1118 is a novel, fully humanized anti-EGFR IgG1 antibody that displays potent inhibitory effects on high-affinity EGFR ligand-induced signaling and enhanced antibody-mediated cytotoxicity. In this study, using 51 CRC patient-derived xenografts (PDXs), we showed that KRAS mutants expressed remarkably elevated autocrine levels of high-affinity EGFR ligands compared with wild-type KRAS. In three KRAS-mutant CRCPDXs, GC1118 was more effective than cetuximab, whereas the two agents demonstrated comparable efficacy against three wild-type KRAS PDXs. Persistent phosphatidylinositol-3-kinase (PI3K)/AKT signaling was thought to underlie resistance to GC1118. In support of these findings, a preliminary improved anti-cancer response was observed in a CRC PDX harboring mutated KRAS with intrinsically high AKT activity using GC1118 combined with the dual PI3K/mammalian target of rapamycin (mTOR)/AKT inhibitor BEZ-235, without observed toxicity. Taken together, the superior antitumor efficacy of GC1118 alone or in combination with PI3K/mTOR/AKT inhibitors shows great therapeutic potential for the treatment of KRAS-mutant mCRC with elevated ratios of high- to low-affinity EGFR ligands and PI3K-AKT pathway activation

Structural and biophysical properties of RIG-I bound to dsRNA with G-U wobble base pairs.

Retinoic acid-inducible gene I (RIG-I) is responsible for innate immunity via the recognition of short double-stranded RNAs in the cytosol. With the clue that G-U wobble base pairs in the influenza A virus's RNA promoter region are responsible for RIG-I activation, we determined the complex structure of RIG-I Delta CARD and a short hairpin RNA with G-U wobble base pairs by X-ray crystallography. Interestingly, the overall helical backbone trace was not affected by the presence of the wobble base pairs; however, the base pair inclination and helical axis angle changed upon RIG-I binding. NMR spectroscopy revealed that RIG-I binding renders the flexible base pair of the influenza A virus's RNA promoter region between the two G-U wobble base pairs even more flexible. Binding to RNA with wobble base pairs resulted in a more flexible RIG-I complex. This flexible complex formation correlates with the entropy-favoured binding of RIG-I and RNA, which results in tighter binding affinity and RIG-I activation. This study suggests that the structure and dynamics of RIG-I are tailored to the binding of specific RNA sequences with different flexibility.11Nsciescopu